PHARMACEUTICAL COMPOSITIONS COMPRISING TIOCONAZOLE AND TERBINAFIN AND METHOD FOR TREATMENT OF ONYCHOMYCOSIS.

Application No. 202122019558

C.B.R. No. 10024 

INVENTOR:

Mr. Ganesh Waghule
Mr. Sagar Magar (Guide)

ABSTRACT:

The present invention Provide a Pharmaceutical compositions comprising Tioconazole and a Terbinafin or salts thereof in an effective amount for the treatment of onychomycosis are provided. A methods for treating onychomycosis using the said compositions delivery by iontophoretic device. 

 (a) Field of the Invention  

The present invention is directed to antifungal Formulation comprising use of two antifungal agents, Tioconazole and a Terbinafin or salts thereof. For treating of onychomycosis. An methods for treating onychomycosis using the said compositions delivery by iontophoretic device.

INVENTOR



Mr. Ganesh Waghule 
(B. Pharmacy)
 
 
Mr. Sagar Magar (Guide)
M.Pharm (Pharmaceutical Chemistry) 
 
Video About Invention:




(c) Objects and Summery of the Invention: 

The present invention generally relates to the treatment of onychomycosis. More specifically, it relates to a formulation for containing Combination therapy of Tioconazole and a Terbinafin or salts thereof for the treatment of onychomycosis and related conditions. 

In a first aspect, the invention provides a combination of Tioconazole and a Terbinafin or salts thereof. 

In second aspect, the invention provides a pharmaceutical composition comprising (a) Tioconazole or salts thereof, (b) Terbinafin or salts thereof, and (c) a pharmaceutically acceptable excipient. The composition may be in a form suitable for topical administration, such as Nail Patch and Solution through delivery by iontophoresis device. 

In another aspect, the invention provides a topical pharmaceutical Solution consisting essentially of Tioconazole and a Terbinafin or salts thereof as the antifungal agents and one or more pharmaceutically acceptable excipients to deliver the Tioconazole and a Terbinafin from the dorsal layer of the nail plate to the nail bed.  

In another aspect, the invention provides a topical pharmaceutical solution comprising (a) Tioconazole or salts thereof, (b) Terbinafin or salts thereof, and (c) a pharmaceutically acceptable excipient. 

In another aspect, the invention provides a combination of Tioconazole and a Terbinafin or salts thereof, and one or more additional antifungal agent. 

In another aspect, the invention provides a pharmaceutical composition comprising (a) Tioconazole, (b) Terbinafin, and (c) a pharmaceutically acceptable excipient which exhibits excellent storage stability. 

A further aspect relates to a device, such as an iontophoretic device, which may include, or be used with, the anti-fungal Tioconazole and a Terbinafin or salts thereof formulation configured for delivery by iontophoresis. 

An additional aspect relates to the use of the device and the Tioconazole and a Terbinafin or salts thereof. Formulation for treatment of an onychomycosis. 

DEVICE DRAWINGS:

Fig 1: Drawing of Iontophoretic device

Fig 2: Schematic flow of Device